Analysis of the algorithm: From rankings to backup genes.

Ranking section

For each of the affected genes present in the list, a ranking with the score and percentile of every possible gene was obtained. Once this was done, the position for every known backup gene was obtained and the statistical descriptor of all the values calculated.

Table 1. Backup position values for every kernel and net before integration.

Net Kernel Elements Min Max Average Standard_Deviation
biological_process ct 1648 0.0 1.0 0.127 0.214
biological_process el 1648 0.0 1.0 0.599 0.268
biological_process ka 1648 0.0 1.0 0.122 0.213
biological_process rf 1648 0.0 1.0 0.127 0.214
cellular_component ct 1649 0.0 0.988 0.239 0.27
cellular_component el 1649 0.002 0.994 0.518 0.295
cellular_component ka 1649 0.0 0.993 0.243 0.269
cellular_component rf 1649 0.0 0.984 0.239 0.27
disease ct 1461 0.0 0.999 0.045 0.143
disease el 1461 0.0 0.999 0.171 0.227
disease ka 1461 0.0 1.0 0.044 0.145
disease rf 1461 0.0 0.999 0.045 0.143
genetic_interaction_weighted ct 1668 0.0 0.998 0.314 0.272
genetic_interaction_weighted el 1668 0.003 0.998 0.521 0.28
genetic_interaction_weighted ka 1668 0.0 0.998 0.312 0.271
genetic_interaction_weighted node2vec 1668 0.0 0.998 0.411 0.304
genetic_interaction_weighted rf 1668 0.0 0.998 0.314 0.272
molecular_function ct 1634 0.0 0.997 0.331 0.303
molecular_function el 1634 0.001 1.0 0.522 0.298
molecular_function ka 1634 0.0 1.0 0.35 0.292
molecular_function rf 1634 0.0 0.997 0.331 0.304
pathway ct 653 0.001 1.0 0.29 0.333
pathway el 653 0.001 1.0 0.339 0.41
pathway ka 653 0.001 1.0 0.543 0.492
pathway node2vec 653 0.0 0.997 0.318 0.348
pathway rf 653 0.001 1.0 0.332 0.41
phenotype ct 1480 0.0 0.998 0.079 0.17
phenotype el 1480 0.0 0.998 0.281 0.213
phenotype ka 1480 0.0 1.0 0.079 0.177
phenotype rf 1480 0.0 0.998 0.079 0.17
protein_interaction ct 1664 0.0 1.0 0.069 0.165
protein_interaction el 1664 0.0 1.0 0.06 0.148
protein_interaction ka 1664 0.0 1.0 0.305 0.456
protein_interaction node2vec 1664 0.0 0.99 0.129 0.2
protein_interaction rf 1664 0.0 1.0 0.061 0.146

Table 2. Backup position values for every kernel after integration

Integration Kernel Elements Min Max Average Standard_Deviation
integration_mean_by_presence ct 1676 0.0 1.0 0.14 0.278
integration_mean_by_presence el 1676 0.0 0.96 0.047 0.119
integration_mean_by_presence ka 1676 0.0 0.977 0.065 0.153
integration_mean_by_presence node2vec 1669 0.0 0.986 0.199 0.251
integration_mean_by_presence rf 1676 0.0 0.943 0.052 0.111
mean ct 1676 0.0 1.0 0.139 0.283
mean el 1676 0.0 0.954 0.036 0.098
mean ka 1676 0.0 0.974 0.04 0.126
mean node2vec 1669 0.0 0.986 0.139 0.208
mean rf 1676 0.0 0.926 0.041 0.101

Backup Pairs Coverage By Layer

CDF plots of non integrated kernels

CDF plots of integrated kernels